Man Utd have been handed a Europa League quarter-final tie against Granada after knocking out AC Milan on Thursday night.
Man Utd, who progessed thanks to a goal from Paul Pogba, will now face the Spanish club in the last eight, with the first leg in Spain.
Arsenal have been drawn against Slavia Prague, who have beaten Leicester and Rangers in the last two rounds, with the first leg being held at the Emirates Stadium.
Ajax have been drawn against Roma in a high-profile tie, while Tottenham’s conquerors Dinamo Zagreb have been drawn against Villarreal.
If Man Utd can get past the Spanish side then they will play either Ajax or Roma in the semi-final.
Arsenal’s reward for beating Slavia Prague would be a last-four tie with Dinamo Zagreb or Villarreal, which could see a possible reunion with former boss Unai Emery.
Granada vs Manchester United
Arsenal vs Slavia Prague
Ajax vs Roma
Dinamo Zagreb vs Villarreal
Granada/Manchester United vs Ajax/Roma
Dinamo Zagreb/Villarreal vs Arsenal/Slavia Prague