The former Real Madrid star will now not be able to play for the Gunners until February after he was also left out of the squad for the Europa League.
Premier League rules state that Arsenal must submit their 25-man squad by 2pm BST (9am ET) on Tuesday and it must include a maximum of 17 non-homegrown players over the age of 21.
Arteta has 19 to choose from, however, due to the club’s failure to move on some fringe players during the summer transfer window, meaning that two senior stars can’t be registered to play during the first half of the season.
Ozil and centre-back Sokratis have been informed they will not make the squad. The decision comes just a week after both were also left out of the squad for the Europa League group stages.
Speaking about his decision not to include the senior pair in his plans for the Europa League, which gets underway on Thursday night when Arsenal visit Rapid Vienna , Arteta said: “I wanted to tell them face to face.
“I explained the reason why and it was really difficult for me to tell them that, but this is the restriction and rules and they have to respect that decision and try to train the best possible way, help the team how they can in that moment and see what happens.”